Current and future microelectronics systems are more and more complex. In a aim to bridge the gap between the cyber world and the physical world we observe the emergence of multi-disciplinary systems that interact more and more with their close surrounding environment. The conception of such systems requires the knowledge of multiple scientific disciplines which tends to define them as heterogeneous systems. Designers of the upcoming digital-centric systems are lacking a common design and simulation environment able to manage all the multi-disciplinary aspects of its components of various nature, which closely interact with each other. We explore the possibilities of developing and deploying a unified SystemC-based design environment for virtual prototyping of heterogeneous systems. To overcome the challenges related to their specification and dimensioning this environment must be able to simulate a heterogeneous system as a whole, for which each component is described and solved using the most appropriate MoC. We propose a simulator prototype called SystemC MDVP which is implemented as an extension of SystemC. It follows a correct-by-construction approach, relies on a hierarchical heterogeneity representation and interaction mechanisms with master-slave semantics in order to model heterogeneous systems. Generic algorithms allow for the elaboration, simulation and monitoring of such systems. A methodology to incorporate new MoCs within SystemC MDVP is defined and followed to add a SPH MoC that enables the description of fluidic network. We modeled a passive RFID reading system using several MoCs. We compare the results with measures acquired on a real physical prototype.